The Doctor of Biomedical Sciences who is keen on cell technologies, immunology and immune therapy in cancer and autoimmune diseases, molecular mechanisms of aging, regenerative medicine, gene and tissue engineering.
EDUCATION:
2015 – 2016 – Master degree in manufacturing of advanced therapy medicinal products, specialization as the qualified person (1 647 hours) related to the Master Program in Manufacturing of Advanced Therapy Medicinal Products, Universidad de Granada/Iniciativa Andaluza en Terapias Avanzadas;
2008 – Ph.D. theses in Immunology, Vilnius University;
2002 – Master degree in molecular biology, Faculty of Natural Sciences, Vilnius University;
2000 – Bachelor degree in molecular biology, Faculty of Natural Sciences, Vilnius University.
SKILLS:
- Qualified person in advanced therapy medical product production and certification;
- Mammalian cell culture;
- Laboratory animal surgery and disease models;
- Methods in molecular biology.
PATENTS:
- Xenogenic normal tissue-derived vaccines for breaking the immune tolerance to tumor-associated antigens, 2016;
- Method of isolation stromal vascular fraction (SVF) cells from adipose tissue and their use, 2015.
LIST OF PUBLICATIONS:
Maciulaitis J, Miskiniene M, Rekštytė S, Bratchikov M, Darinskas A, Simbelyte A, Daunoras G, Laurinaviciene A, Laurinavicius A, Gudas R, Malinauskas M, Maciulaitis R. Cartilage. 2019 May 9:1947603519847745. doi: 10.1177/1947603519847745. PMID: 31072136
Kazlauskas A, Darinskas A, Meškys R, Tamašauskas A, Urbonavičius J.
BMC Cancer. 2019 Mar 4;19(1):197. doi: 10.1186/s12885-019-5409-7. PMID:30832616
Michalek J, Vrablikova A, Darinskas A, Lukac L, Prucha J, Skopalik J, Travnik J, Cibulka M, Dudasova Z. J Clin Orthop Trauma. 2019 Jan-Feb;10(1):76-80. doi: 10.1016/j.jcot.2018.11.010. Epub 2018 Nov 23. PMID: 30705536
Dobrovolskienė N, Pašukonienė V, Darinskas A, Kraśko JA, Žilionytė K, Mlynska A, Gudlevičienė Ž, Mišeikytė-Kaubrienė E, Schijns V, Lubitz W, Kudela P, Strioga M. Vaccine. 2018 Jul 5;36(29):4171-4180. doi: 10.1016/j.vaccine.2018.06.016. Epub 2018 Jun 9. PMID: 29895501
Kraśko JA, Žilionytė K, Darinskas A, Dobrovolskienė N, Mlynska A, Riabceva S, Zalutsky I, Derevyanko M, Kulchitsky V, Karaman O, Fedosova N, Symchych TV, Didenko G, Chekhun V, Strioga M, Pašukonienė V. Oncol Lett. 2018 Apr;15(4):5098-5104. doi: 10.3892/ol.2018.7950. Epub 2018 Feb 5. PMID: 29552144
- Scaffold design for artificial tissue with bone marrow stem cells.
Noreikaitė A, Antanavičiūtė I, Mikalayeva V, Darinskas A, Tamulevičius T, Adomavičiūtė E, Šimatonis L, Akramienė D, Stankevičius E. Medicina (Kaunas).. 2017;53(3):203-210. doi: 10.1016/j.medici.2017.07.001. - Stromal vascular fraction cells for the treatment of critical limb ischemia: a pilot study.
Darinskas A, Paskevicius M, Apanavicius G, Vilkevicius G, Labanauskas L, Ichim TE, Rimdeika R. J Transl Med. 2017 Jun 19;15(1):143. doi: 10.1186/s12967-017-1243-3. - Bacterial ghosts as adjuvants in syngeneic tumour cell lysate-based anticancer vaccination in a murine lung carcinoma model.
Kraśko JA, Žilionytė K, Darinskas A, Strioga M, Rjabceva S, Zalutsky I, Derevyanko M, Kulchitsky V, Lubitz W, Kudela P, Miseikyte-Kaubriene E, Karaman O, Didenko H, Potebnya H, Chekhun V, Pašukonienė V.Oncol Rep. 2017 Jan;37(1):171-178. doi: 10.3892/or.2016.5252. Epub 2016 Nov 16. - Preclinical study of SZ2080 material 3D microstructured scaffolds for cartilage tissue engineering made by femtosecond direct laser writing lithography.
Mačiulaitis J, Deveikytė M, Rekštytė S, Bratchikov M, Darinskas A, Šimbelytė A, Daunoras G, Laurinavičienė A, Laurinavičius A, Gudas R, Malinauskas M, Mačiulaitis R. Biofabrication.. 2015 Mar 23;7(1):015015. doi: 10.1088/1758-5090/7/1/015015. - Immune responses induced by T-cell vaccination in patients with rheumatoid arthritis.
Ivanova I.P, Seledtsova G.V., Mamaev S.V., Shishkov A.A., Seledtsov V.I. Human Vaccines & Immunotherapeutics.. 2014; 10: 1-7. - Xenogeneic therapeutic cancer vaccines as breakers of immune tolerance for clinical application: to use or not to use?
Strioga MM, Darinskas A, Pasukoniene V, Mlynska A, Ostapenko V, Schijns V. Vaccine.2014 Jul 7;32(32):4015-24. doi: 10.1016/j.vaccine.2014.05.006. Epub 2014 May 14. Review. - Same or not the same? Comparison of adipose tissue-derived versus bone marrow-derived mesenchymal stem and stromal cells.
Strioga M, Viswanathan S, Darinskas A, Slaby O, Michalek J. Stem Cells Dev.. 2012 Sep 20;21(14):2724-52. doi: 10.1089/scd.2011.0722. Epub 2012 May 9. Review. - Protein oligomerization induced by oleic acid at the solid-liquid interface–equine lysozyme cytotoxic complexes.
Wilhelm K, Darinskas A, Noppe W, Duchardt E, Mok KH, Vukojević V, Schleucher J, Morozova-Roche LA. FEBS J.. 2009 Aug;276(15):3975-89. doi: 10.1111/j.1742-4658.2009.07107.x. Epub 2009 Jul 7. - Engrafting fetal liver cells into multiple tissues of healthy adult mice without the use of immunosuppressants.
Darinskas A, Gasparaviciute R, Malisauskas M, Wilhelm K, Kozhevnikov JA, Liutkevicius E, Pilinkiene A, Morozova-Roche LA. Cell Mol Biol Lett. 2007 Sep;12(3):422-34. doi: 10.2478/s11658-007-0013-2. Epub 2007 May 10. - Immune reactivity towards insulin, its amyloid and protein S100B in blood sera of Parkinson’s disease patients.
Wilhelm KR, Yanamandra K, Gruden MA, Zamotin V, Malisauskas M, Casaite V, Darinskas A, Forsgren L, Morozova-Roche LA. Eur J Neurol. 2007 Mar;14(3):327-34. - Intermediate amyloid oligomers of lysozyme: Is their cytotoxicity a particular case or general rule for amyloid?
Malisauskas M, Darinskas A, Zamotin VV, Gharibyan A, Kostanyan IA, Morozova-Roche LA. Biochemistry (Mosc). 2006 May;71(5):505-12. - Does the cytotoxic effect of transient amyloid oligomers from common equine lysozyme in vitro imply innate amyloid toxicity?
Malisauskas M, Ostman J, Darinskas A, Zamotin V, Liutkevicius E, Lundgren E, Morozova-Roche LA. J Biol Chem. 2005 Feb 25;280(8):6269-75. Epub 2004 Dec 1.
